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・ Proteans
・ Proteas (rugby union)
・ Proteas of Macedon
・ Proteas Voulas B.C.
・ Protease
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・ Protease accumulated by inhibitors
・ Protease inhibitor
・ Protease inhibitor (biology)
・ Protease inhibitor (pharmacology)
・ Protease VII
・ Protease-activated receptor
・ Protease-activated receptor 2
・ Protease-sensitive prionopathy
・ Protease-sparing regimen
Proteases (medical and related uses)
・ Proteases in angiogenesis
・ Proteasome
・ Proteasome (prosome, macropain) subunit, alpha 1
・ Proteasome ATPase
・ Proteasome endopeptidase complex
・ Proteasome inhibitor
・ Protección
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Proteases (medical and related uses) : ウィキペディア英語版
Proteases (medical and related uses)
Proteases (also sometimes referred to as ''proteolytic enzymes'' or ''peptidases'') are in use, or have been proposed or tried, for a number of purposes related to medicine or surgery. Some preparations involving protease have undergone successful clinical trials and have regulatory authorization;〔See Tissue plasminogen activator and Maggot therapy.〕 and some further ones have shown apparently useful effects in experimental medical studies.〔Examples are reported by M. Mecikoglu et al., "The Effect of Proteolytic Enzyme Serratiopeptidase in the Treatment of Experimental Implant-Related Infection", ''The Journal of Bone and Joint Surgery (American)'' vol.88 (2006), pp.1208-1214; see also bromelain and papain.〕 Proteases have also been used by proponents of alternative therapies, or identified in materials of traditional or folk medicine.〔Examples include Serratia E-15 protease (Serratiopeptidase) (see also separate references in this list); Wobenzym (a mixture of bromelain and papain); and Maggot therapy.〕 A serine protease of human origin, activated protein C, was produced in recombinant form and marketed as Drotrecogin alfa (also known as Xigris (TM)) and licensed for intensive-care treatment of severe sepsis. It was voluntarily withdrawn by the manufacturer in 2011 after being shown to be ineffective.〔http://www.businessweek.com/news/2011-10-25/lilly-pulls-xigris-off-markets-after-sepsis-drug-fails-study.html〕
Some of these uses rely directly on the proteolytic activity: others rely on observations of anti-inflammatory activity.
==Medical and surgical applications based on proteolytic effect==


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